WASHINGTON (Reuters) - The U.S. Environmental Protection Agency proposed a rule on Tuesday that would limit the kinds of scientific research it can use in crafting regulations, an apparent concession to big business that has long requested such restrictions.

WASHINGTON (Reuters) - U.S. President Donald Trump on Tuesday left open the possibility that his doctor, Ronny Jackson, would withdraw as his pick to lead the Veterans Affairs department after allegations stalled his Senate confirmation hearing.

(Reuters) - London-listed drugmaker Shire Plc and Japan‘s Takeda Pharmaceutical Co Ltd plan to announce a preliminary deal on Wednesday, after the latter sweetened its 62 billion acquisition offer, people familiar with the matter said.

NEW YORK (Reuters) - U.S. stocks slid on Tuesday as 10-year Treasury yields hit 3 percent for the first time in four years, stoking concerns over higher borrowing rates for companies already facing rising costs, and as quarterly results failed to deliver positive outlooks.

NEW YORK (Reuters) - Bitcoin rose to a six-week high on Tuesday on positive headlines that included the possible entry of major financial institutions into the space, lifting sentiment on the overall cryptocurrency market.

WASHINGTON (Reuters) - The Environmental Protection Agency announced a new rule on Tuesday that would stop it from relying on scientific research underpinned by confidential data in its making of regulations.

TORONTO (Reuters) - The man accused of plowing a rental van into pedestrians on a crowded Toronto sidewalk, killing 10 people, in Canada‘s deadliest mass killing in decades left a "cryptic message" on social media before his attack, police said on Tuesday.

TORONTO (Reuters) - The man accused of plowing a rental van into pedestrians on a crowded Toronto sidewalk, killing 10 people, in Canada‘s deadliest mass killing in decades left a "cryptic message" on social media before his attack, police said on Tuesday.

WASHINGTON (Reuters) - President Donald Trump and French President Emmanuel Macron pledged on Tuesday to seek stronger measures to contain Iran, as the U.S. leader considers whether to ditch an international accord meant to prevent Tehran from obtaining a nuclear weapon.

LOS ANGELES (Reuters) - The largest U.S. manager of prescription benefits is telling drugmakers that the current pricing model is broken, and taking aim at Amgen Inc, Eli Lilly and Co and other makers of new migraine medicines to try and fix it.

(Reuters) - Wall Street dropped sharply on Tuesday as concerns over marquee companies warning of higher costs were exacerbated by the benchmark U.S. 10-year Treasury yield piercing the 3-percent level for the first time in four years.

WASHINGTON (Reuters) - U.S. President Donald Trump and French President Emmanuel Macron pledged on Tuesday to try to resolve U.S.-European differences on Iran but Trump gave no clear signal about whether he would carry out a threat to abandon an international nuclear deal with Tehran.

TORONTO (Reuters) - The man accused of plowing a rental van into pedestrians on a crowded Toronto sidewalk in Canada‘s deadliest mass killing in decades was charged with 10 counts of first-degree murder on Tuesday, as police probed what motivated his rampage.

WASHINGTON (Reuters) - U.S. consumer confidence rebounded in April and new home sales increased more than expected in March, pointing to underlying strength in the economy despite signs that growth slowed in the first quarter.

(Reuters) - Coca-Cola Co said on Tuesday it would take a hit in the second quarter from the introduction of a British sugar tax on soft drinks and rising freight costs in the United States, overshadowing modestly better than forecast results for the first three months of 2018.

(Reuters) - A sharp drop in so-called ‘FAANG‘ group of technology stocks pushed the Nasdaq Composite lower on Tuesday, with rising 10-year yields and contrasting earnings reports from industrials also adding to the pressure.

WASHINGTON (Reuters) - U.S. President Donald Trump warned Iran on Tuesday not to follow through with threats to restart its nuclear program, as he and French President Emmanuel Macron struggled to find common ground on saving the 2015 Iran nuclear deal.

TORONTO (Reuters) - The driver accused of plowing a rental van into pedestrians in Toronto was charged with 10 counts of first-degree murder and 13 counts of attempted murder at his first court appearance on Tuesday, but his motive remained a mystery.

RIO DE JANEIRO(Reuters) - Leaders of Rio de Janeiro‘s heavily armed drug gangs agree on at least one thing with the head of Brazil‘s army: An ongoing military intervention cannot solve the soaring crime and violence that is roiling the seaside metropolis.

(Reuters) - U.S. stocks turned negative on Tuesday, weighed down by shares of Alphabet and 3M and as yield on the 10-year Treasury notes US10YT=RR rose to 3 percent for the first time in more than four years.

WASHINGTON (Reuters) - U.S. consumer confidence rebounded in April and new home sales increased more than expected in March, pointing to underlying strength in the economy despite signs that growth slowed in the first quarter.

TORONTO (Reuters) - The driver suspected of killing 10 people and injuring 15 others when he plowed a rental van into pedestrians in Toronto made his first court appearance on Tuesday, where details of a motive for the attack were expected to emerge.

(Reuters) - U.S. stocks rose on Tuesday as strong earnings from Caterpillar, Verizon and a host of other big names boosted optimism about corporate America‘s health, but the gains were curbed by rising bond yields.

WASHINGTON (Reuters) - U.S. President Donald Trump treated French President Emmanuel Macron to a colorful welcome ceremony at the White House on Tuesday during a state visit that threatened to expose differences on Iran, trade and Syria between two close allies.