Two former semi-finalists have been paired together in the round of 16 as Eintracht Frankfurt go head to head for the first time with Basel.
As the round of 16 comes to a conclusion, UEFA.com presents a captaincy option for each of the four gamedays.
Ahead of Matchday 8, UEFA.com looks at some obvious #UCLfantasy selections and those who could cause a surprise.
Standing between Wolfsburg and a third UEFA Europa League quarter-final are Shakhtar Donetsk as the clubs meet for the first time.
stanbul Baakehir and F. C. Copenhagen are each aiming to reach the quarter-finals of a European competition for the first time.
Rangers‘ marathon UEFA Europa League campaign stretches into a 17th fixture as they play host to German heavyweights Bayer Leverkusen.
Olympiacos‘s reward for a dramatic victory against 2019 runners-up Arsenal is another tie against English opposition, Wolverhampton Wanderers.
Conquerors of Ajax in the round of 32, Getafe‘s reward is another tie against esteemed European campaigners as they take on Italian giants Internazionale.
Two clubs whose campaigns started in the group stage meet in the last 16 with Sevilla hosting Roma at the Estadio Ramn Snchez-Pizjun.
The longest European campaign in Austrian club LASK‘s history continues with a mouth-watering home fixture against Manchester United.
Home advantage could be key with 13 of the 15 players in The Scout‘s squad playing second legs on their own ground.
Basel have one foot in the quarter-finals after overwhelming 2018/19 semi-finalists Eintracht Frankfurt 3-0 away in the first leg of their round of 16 tie.
LASK‘s longest European campaign looks set to end as they travel to Manchester United having lost 5-0 at home in the first leg of their last-16 tie.
Bayer Leverkusen appear to be in complete control of this UEFA Europa League round of 16 tie after beating Rangers 3-1 in the Glasgow first leg.
Shakhtar Donetsk have the edge in the tie after a 2-1 win in Germany, but Wolfsburg boast an excellent UEFA Europa League away record.
After a 1-1 draw in Piraeus, Wolverhampton Wanderers and Olympiacos meet at Molineux to decide their round of 16 tie.
Copenhagen welcome stanbul Baakehir to Denmark with the Turkish club holding a 1-0 lead as both clubs seek a first European quarter-final appearance.
UEFA.com studies the statistics to find out which players are predicted for big Matchday 8 totals.