Barcelona egded to victory at Paris Saint-Germain while Manchester City beat Inter in an epic shoot-out as the first two round of 16 ties were played on Tuesday.
All you need to know as Shakhtar and Roma lock horns again in the round of 16, seven years after the Pitmen emerged victorious their sole triumph at this stage.
The draw on 9 February paved the path from the round of 16 to the April finals in Nyon: see the full knockout tree and match schedule.
UEFA Youth League matches are being streamed live on UEFA.com this season; see which round of 16 matches will be shown and check out the best of the action so far.
They may not have the most supporters in Turkey, but quarter-finalists Beikta claim the loudest fans and the best views from the banks of the Bosporus; UEFA.com salutes the Black Eagles.